Issue 11, 2010
From the journal:

Natural Product Reports

Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity

Bohdan Ostashac  and  Suzanne Walker*ab  

* Corresponding authors

a Harvard Medical School, Department of Microbiology and Molecular Genetics, 200 Longwood ave., Armenise bldg. 2, Rm 630, Boston, MA, USA
E-mail: suzanne_walker@hms.harvard.edu
Tel: +1-617-4325488

b Harvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA

c Ivan Franko National University of L'viv, Department of Genetics and Biotechnology, L'viv, Ukraine

Abstract

Covering: up to May 2010

This review (with 214 references cited) is devoted to moenomycins, the only known group of antibiotics that directly inhibit bacterial peptidoglycan glycosytransferases. Naturally occurring moenomycins and chemical and biological approaches to their derivatives are described. The biological properties of moenomycins and plausible mechanisms of bacterial resistance to them are also covered here, portraying a complete picture of the chemistry and biology of these fascinating natural products.

Graphical abstract: Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity

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Article information

DOI
https://doi.org/10.1039/C001461N
Article type
Review Article
Submitted
03 Jun 2010
First published
23 Aug 2010

Nat. Prod. Rep., 2010,27, 1594-1617

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Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity

B. Ostash and S. Walker, Nat. Prod. Rep., 2010, 27, 1594 DOI: 10.1039/C001461N

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