Issue 6, 2010
From the journal:

New Journal of Chemistry

The first use of supramolecular recognition to extract and stabilize an enzymatic inhibitor of a coagulation process†

Arnaud Grandeury,‡ab   Claudette Martin,a   Samuel Petit,b   Constantin T. Craescu§c  and  Géraldine Gouhier*a  

* Corresponding authors

a UMR CNRS 6014, Université de Rouen, IRCOF, 1 Rue Tesnière, France
E-mail: geraldine.gouhier@univ-rouen.fr
Fax: +33 235522959
Tel: +33 235522909

b UPRES EA 3233, SMS, IRCOF, Université de Rouen, 1 Rue Tesnière, France

c INSERM U759/Institut Curie-Centre de Recherche, Centre Universitaire Paris-Sud, Bâtiment 112, France

Abstract

A supramolecular complex based on salt bridges between an artificial receptor and (Z,Z)-(BABCH), a synthetic antagonist of tissue-plasminogen activator (t-PA), leads to a notable increase of its stability in solution and a new purification route for this bioactive isomer.

Graphical abstract: The first use of supramolecular recognition to extract and stabilize an enzymatic inhibitor of a coagulation process

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Article information

DOI
https://doi.org/10.1039/C0NJ00147C
Article type
Letter
Submitted
23 Feb 2010
Accepted
12 Apr 2010
First published
06 May 2010

New J. Chem., 2010,34, 1089-1093

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The first use of supramolecular recognition to extract and stabilize an enzymatic inhibitor of a coagulation process

A. Grandeury, C. Martin, S. Petit, C. T. Craescu and G. Gouhier, New J. Chem., 2010, 34, 1089 DOI: 10.1039/C0NJ00147C

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