Issue 11, 2010
From the journal:

Metallomics

Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates†

Jade Durand,‡ab   Gabriele Meloni,§c   Christine Talmard,ab   Milan Vašákc  and  Peter Faller*ab  

* Corresponding authors

a CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France
E-mail: peter.faller@lcc-toulouse.fr
Fax: 0033/561553003

b Université de Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France

c Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Abstract

The reactive oxygen species H2O2 promotes the Zn7-metallothionein-3 induced Aβ40 aggregation of fibrillar type structures via slow cysteine oxidation and Zn2+ release, whereas amorphous aggregates are formed by addition of Zn2+ to Aβ40.

Graphical abstract: Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates

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Article information

DOI
https://doi.org/10.1039/C0MT00027B
Article type
Communication
Submitted
02 Jul 2010
Accepted
04 Oct 2010
First published
21 Oct 2010

Metallomics, 2010,2, 741-744

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