Structure and antibacterial activity of the silver(I) complex of 2-aminophenoxazine-3-one

Komala Pandurangan; Shane Gallagher; Grace G. Morgan; Helge Müller-Bunz; Francesca Paradisi

doi:10.1039/C003515G

Structure and antibacterial activity of the silver(i) complex of 2-aminophenoxazine-3-one†

Komala Pandurangan,^a Shane Gallagher,^a Grace G. Morgan,*^ab Helge Müller-Bunz^a and Francesca Paradisi^a

* Corresponding authors

^a Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland
E-mail: grace.morgan@ucd.ie
Fax: +353 1 7161178
Tel: +353 1 7162295

^b SFI—Strategic Research Cluster in Solar Energy Conversion, University College Dublin, Belfield, Dublin 4, Ireland
E-mail: grace.morgan@ucd.ie
Fax: +353 1 7161178
Tel: +353 1 7162295

Abstract

The crystal structure and antibacterial activity of the first metal complex of 2-aminophenoxazine-3-one is reported. We describe the silver(I) complex of this important biological molecule and show that the binding mode is through the phenoxazine ring nitrogen. A new synthetic route to 2-aminophenoxazine-3-one is also reported.

Metallomics

Structure and antibacterial activity of the silver(i) complex of 2-aminophenoxazine-3-one†

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