Issue 4, 2010
From the journal:

MedChemComm

Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry†

Anh Thu Tran,a   Katie M. Cergol,a   Warwick J. Britton,b   Syed Ali Imran Bokhari,c   Musadiq Ibrahim,c   Adrian J. Lapthornc  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Building F11, Sydney, Australia
E-mail: richard.payne@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 5877

b Faculty of Medicine, Blackburn Building, The University of Sydney, NSW 2006, Australia and Mycobacterial Research Program, Centenary Institute, Australia

c Department of Chemistry and Division of Biochemistry and Life Science, University of Glasgow, UK

Abstract

The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(I)-catalysed azide-alkynecycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.

Graphical abstract: Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

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Article information

DOI
https://doi.org/10.1039/C0MD00097C
Article type
Concise Article
Submitted
02 Jul 2010
Accepted
20 Jul 2010
First published
23 Aug 2010

Med. Chem. Commun., 2010,1, 271-275

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Rapid assembly of potent type II dehydroquinase inhibitorsvia “Click” chemistry

A. T. Tran, K. M. Cergol, W. J. Britton, S. A. Imran Bokhari, M. Ibrahim, A. J. Lapthorn and R. J. Payne, Med. Chem. Commun., 2010, 1, 271 DOI: 10.1039/C0MD00097C

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