Issue 3, 2010
From the journal:

MedChemComm

Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents†

Cristina Pessoa Veloso Freire,a   Sabrina Baptista Ferreira,b   Nivea Suely Melo de Oliveira,a   Ani Beatriz Jackisch Matsuura,c   Ivson Lelis Gama,b   Fernando de C. da Silva,b   Maria Cecília B. V. de Souza,b   Emerson Silva Limaa  and  Vitor Francisco Ferreira*b  

* Corresponding authors

a Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Manaus, AM, Brazil

b Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, CEG, Niterói, RJ, Brazil
E-mail: cegvito@vm.uff.br
Fax: +55 21 26292362
Tel: +55 21 26292345

c Centro de Pesquisas Leônidas Maria Deane, Fundação Oswaldo Cruz–FIOCRUZ, Manaus, AM, Brazil

Abstract

We report herein, the synthesis and antifungal activity of substituted α- and β-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium(IV) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida (C.): C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. tropicalis and C. dubliniensis. In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these fungi, indicating that they are important scaffolds and potential novel antifungal agents.

Graphical abstract: Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

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Article information

DOI
https://doi.org/10.1039/C0MD00074D
Article type
Concise Article
Submitted
07 Jun 2010
Accepted
08 Jul 2010
First published
04 Aug 2010

Med. Chem. Commun., 2010,1, 229-232

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Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agents

C. P. V. Freire, S. B. Ferreira, N. S. M. de Oliveira, A. B. J. Matsuura, I. L. Gama, F. D. C. da Silva, M. C. B. V. de Souza, E. S. Lima and V. F. Ferreira, Med. Chem. Commun., 2010, 1, 229 DOI: 10.1039/C0MD00074D

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