Issue 1, 2010

Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

Abstract

Here we describe an automated synthetic pathway for the synthesis of fluorocarbon oligonucleotide conjugates (FONs) featuring fluorocarbon hydrophobic and lipophobic moieties. The presence of highly fluorinated chains allows the delivery of nucleic acids into human cells.

Graphical abstract: Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

Supplementary files

Article information

Article type
Concise Article
Submitted
22 Apr 2010
Accepted
18 May 2010
First published
04 Jun 2010

Med. Chem. Commun., 2010,1, 76-78

Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

G. Godeau, H. Arnion, C. Brun, C. Staedel and P. Barthélémy, Med. Chem. Commun., 2010, 1, 76 DOI: 10.1039/C0MD00054J

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