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Issue 20, 2010
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Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

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Abstract

Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.

Graphical abstract: Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

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Article information


Submitted
03 Jun 2010
Accepted
06 Aug 2010
First published
31 Aug 2010

Lab Chip, 2010,10, 2655-2658
Article type
Communication

Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

S. R. Corrie, G. J. P. Fernando, M. L. Crichton, M. E. G. Brunck, C. D. Anderson and M. A. F. Kendall, Lab Chip, 2010, 10, 2655
DOI: 10.1039/C0LC00068J

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