Issue 11, 2010
From the journal:

Lab on a Chip

In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors†

Takahiro Nitta,*a   Akihito Tanahashia  and  Motohisa Hiranoa  

* Corresponding authors

a Department of Mathematical and Design Engineering, Gifu University, Gifu, Japan
E-mail: nittat@gifu-u.ac.jp
Fax: +81-58-230-1891
Tel: +81-58-293-2551

Abstract

We present an extended computer simulation method which allows in silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors. The simulation reproduced molecular shuttle movements under external forces and dissociation of shuttles from guiding track surfaces. The simulation was validated by comparing the simulation results with the corresponding experimental ones. Using the simulation, track designers can change guiding track designs, choose guiding methods, tune the strength of external forces, and test the module performance. This simulation would significantly reduce the effort expended in designing guiding tracks for molecular shuttles powered by kinesin motors.

Graphical abstract: In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors

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Article information

DOI
https://doi.org/10.1039/B926210E
Article type
Paper
Submitted
11 Dec 2009
Accepted
16 Feb 2010
First published
16 Mar 2010

Lab Chip, 2010,10, 1447-1453

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In silico design and testing of guiding tracks for molecular shuttles powered by kinesin motors

T. Nitta, A. Tanahashi and M. Hirano, Lab Chip, 2010, 10, 1447 DOI: 10.1039/B926210E

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