Jump to main content
Jump to site search

Issue 1, 2010
Previous Article Next Article

A nano-needle/microtubule composite gliding on a kinesin-coated surface for target molecule transport

Author affiliations

Abstract

An alternative method of micro/nano-transport has been achieved by using motor proteins. Microtubules on a kinesin-coated surface have potential to act as a nano-transport system. When microtubules are used as carriers, either cargo or cargo linkers are attached on the microtubule surface. Such cargo attachments can significantly affect kinesin motion. To deal with the difficulty caused by molecular attachment to the microtubule surface, the cargo loading and transport mechanism should be separated. In this work, we propose to use micromachined needles as cargo carriers which then can be transported on microtubules. Because of the separation of needle functionalization and transport mechanism, functionalization of the needles can proceed without any effect on the microtubule structure, significantly increasing the possible types of cargo. We have fabricated silicon needles in mass numbers using a simple and effective method and have shown that the microtubule–needle composites are transported without affecting the kinesin activity.

Graphical abstract: A nano-needle/microtubule composite gliding on a kinesin-coated surface for target molecule transport

Back to tab navigation

Supplementary files

Article information


Submitted
06 Jul 2009
Accepted
14 Oct 2009
First published
10 Nov 2009

Lab Chip, 2010,10, 86-91
Article type
Paper

A nano-needle/microtubule composite gliding on a kinesin-coated surface for target molecule transport

M. C. Tarhan, R. Yokokawa, C. Bottier, D. Collard and H. Fujita, Lab Chip, 2010, 10, 86
DOI: 10.1039/B913312G

Social activity

Search articles by author

Spotlight

Advertisements