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Issue 41, 2010
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99mTc-hematoporphyrin linked albumin nanoparticles for lung cancer targeted photodynamic therapy and imaging

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Abstract

In this study, we fabricated albumin nanoparticles (ANP) using a solvent diffusion method and modified the surface of the ANP with hematoporphyrin (HP) which has been used for cancer photodynamic therapy. Hematoporphyrin linked albumin nanoparticles (HP-ANP) were further functionalized with gamma-emitting nuclides (99mTc) for scintigraphic imaging. The fabrication method for HP-ANP was optimized extensively to obtain HP-ANP particles within the size range of 100 to 200 nm. HP-ANP had enhanced accumulation in A549 and CT-26 cancer cell lines, and photodynamic activity against A549 cells after UV exposure. HP-ANP also showed increased accumulation in murine lung tumors, which was induced by CT-26 colon cancer cells, compared to normal lungs. Pharmacokinetics of 99mTc chelated HP-ANP (99mTc-HP-ANP) was estimated through scintigraphic imaging of rabbits. 99mTc-HP-ANP demonstrated good imaging properties in the rabbit with a much more extended biological half life compared to 99mTc-HP. 99mTc-HP-ANP could be utilized as a radio-diagnostic tool for cancer as well as the obvious application for photodynamic therapy.

Graphical abstract: 99mTc-hematoporphyrin linked albumin nanoparticles for lung cancer targeted photodynamic therapy and imaging

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Publication details

The article was received on 21 May 2010, accepted on 14 Jul 2010 and first published on 13 Sep 2010


Article type: Paper
DOI: 10.1039/C0JM01544J
Citation: J. Mater. Chem., 2010,20, 9042-9046

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    99mTc-hematoporphyrin linked albumin nanoparticles for lung cancer targeted photodynamic therapy and imaging

    S. Yang, J. Chang, B. Shin, S. Park, K. Na and C. Shim, J. Mater. Chem., 2010, 20, 9042
    DOI: 10.1039/C0JM01544J

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