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Issue 45, 2010
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A nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays

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Abstract

A nanofibrous membrane fabricated by electrospinning (ES) technology has found a pyramid of promising applications; to satisfy the demand of various applications, nanofibrous membranes with tunable surface chemistry are needed, and thus effective surface modification strategies for functionalizing nanofibers are highly desired. To this end, we herein report a general and convenient method to functionalize ES nanofibers. We have developed a technology that produces ES nanofibers with initiators covalently anchored on the fiber surface, which we term as iES. Subsequently, the iES nanofibers are used as a general scaffold for surface modification via surface initiated polymerization (SIP). The tunable surface chemistry, determined by application needs, was realized by the choice of specific monomers for SIP, which resulted in the desired functional polymer surface. The nanofibrous membrane modified via this method was demonstrated as the substrate for protein microarrays, showing excellent performance. Given the generality and simplicity of this method, we believe that the combination of iES and SIP will be a robust platform for extending the application of ES nanofibers.

Graphical abstract: A nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays

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Article information


Submitted
11 May 2010
Accepted
29 Jul 2010
First published
29 Sep 2010

J. Mater. Chem., 2010,20, 10228-10233
Article type
Paper

A nanofibrous membrane with tunable surface chemistry: preparation and application in protein microarrays

X. Liu, D. Yang, G. Jin and H. Ma, J. Mater. Chem., 2010, 20, 10228
DOI: 10.1039/C0JM01409E

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