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Issue 36, 2010
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Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation

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Abstract

Various nanoparticles are used to fabricate innovative systems for drug encapsulation and cancer therapy. In this paper, the hierarchical core-shell nanostructures composed of gold nanoparticles and poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) block copolymers are fabricated via a hydrosilylation reaction. The obtained gold/copolymer nanocomposites display a desired amphiphilic property and can be well-dispersed in water when the PEG blocks are long enough. The hydrophobic drug hypocrellin B (HB) can be encapsulated into these water-dispersible nanocomposites based on the hydrophobic-hydrophobic interaction between HB molecules and PDMS segments. The gold/copolymer nanocomposites loaded with HB show a rational anticancer ability in the photodynamic therapy although the gold/copolymer nanocomposites without drug also have a little cytotoxicity. Such hierarchically structured core-shell nanocomposites can be considered as water-dispersible nanotanks for hydrophobic drugs in the development of multifunctional biodelivery systems.

Graphical abstract: Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation

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Publication details

The article was received on 16 Apr 2010, accepted on 16 Jun 2010 and first published on 03 Aug 2010


Article type: Paper
DOI: 10.1039/C0JM01059F
J. Mater. Chem., 2010,20, 7782-7787

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    Hierarchical gold/copolymer nanostructures as hydrophobic nanotanks for drug encapsulation

    D. Li, C. Li, A. Wang, Q. He and J. Li, J. Mater. Chem., 2010, 20, 7782
    DOI: 10.1039/C0JM01059F

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