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Issue 26, 2010
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Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

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Abstract

The work is directed toward the synthesis and characterization of gold nanoparticles coated by Gd-chelate (Au@GdL), where L is a conjugate of diethylenetriamine-N,N,N′,N′′,N′′-pentaacetic acid (DTPA) and penicillamine. Au@GdL is obtained by the replacement of citrate from Au@citrate with gadolinium chelate (GdL). The average size of Au@GdL is 12 nm with the loading of GdL reaching up to 3.0 × 103 per particle, and they exhibit very high r1 relaxivity (∼107 mM−1 s−1) as well as X-ray attenuation. The r1 relaxivity per [Gd] is 20.1 mM−1 s−1. The small size of the present system also exhibits a USPIO-like behavior, such as contrast enhancement in the liver, the blood pool and the lymph node, as demonstrated by histological and TEM images, as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent with potential application to the blood pool and the lymph node.

Graphical abstract: Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

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Submitted
26 Jan 2010
Accepted
06 Apr 2010
First published
01 Jun 2010

J. Mater. Chem., 2010,20, 5411-5417
Article type
Paper

Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

H. Kim, H. Jung, J. Park, M. Huh, J. Jung, Y. Chang and T. Kim, J. Mater. Chem., 2010, 20, 5411
DOI: 10.1039/C0JM00163E

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