Issue 3, 2010
From the journal:

Journal of Materials Chemistry

Complete separation of magnetic nanoparticlesvia chemical cleavage of dextran by ethylenediamine for intracellular uptake†

Meng Meng Lin,a   Shanghua Li,b   Hyung-Hwan Kim,cd   Hyuck Kim,de   Hyung Bock Lee,f   Mamoun Muhammedb  and  Do Kyung Kim*abd  

* Corresponding authors

a Institute for Science and Technology in Medicine, Keele University, Thhornburrow Drive, Hartshill, UK
E-mail: d.k.kim@pmed.keele.ac.uk
Fax: +44 (0) 1782 717079
Tel: +44 (0)1782 55 4600

b Electrum 229, Isafjordsgatan 22, Royal Institute of Technology (KTH), SE-16 440 Kista, Stockholm, Sweden
Fax: +46 8 790 8148
Tel: + 46 8 790 9072

c Vascular Medicine Research Unit, Brigham & Women's Hospital, Harvard Medical School, Cambridge
Fax: +1 617 768 8421
Tel: +1 617 768 8415

d International Research Center of Bioscience and Biotechnology, Jungwon University, Goesan-gun, Chungcheongbuk-do, Korea

e Faculty of Herb Industry, Jungwon University, Goesan-gun, Chungcheongbuk-do, Korea

f Department of Materials Science and Engineering, Myong-Ji University, South Korea
Tel: +82 31 330 6459

Abstract

Completely water dispersible and highly monodispersed superparamagnetic iron oxide nanoparticles (SPIONs) were prepared. The surface of SPIONs was modified with dual-crosslinked amine activated dextran (AMD) and chemical cleavage of AMD on SPIONs was carried out by ethylenediamine hydrochloride (EDA). Transmission electron microscopy (TEM) revealed that individual SPIONs were completely separated in water and the average diameter of resulting nanoparticles was 4.4 nm.

Graphical abstract: Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

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Article information

DOI
https://doi.org/10.1039/B918416C
Article type
Communication
Submitted
08 Sep 2009
Accepted
28 Oct 2009
First published
11 Nov 2009

J. Mater. Chem., 2010,20, 444-447

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Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

M. M. Lin, S. Li, H. Kim, H. Kim, H. B. Lee, M. Muhammed and D. K. Kim, J. Mater. Chem., 2010, 20, 444 DOI: 10.1039/B918416C

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