Issue 8, 2009
From the journal:

Molecular BioSystems

The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase

Maria Fairbank,†a   Pascal St-Pierre†a  and  Ivan R. Nabi*a  

* Corresponding authors

a Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6P 5V8, Canada
E-mail: irnabi@interchange.ubc.ca

Abstract

Phosphoglucose isomerase (PGI) is a glycolytic enzyme that exhibits a dual function as an extracellularcytokine, under the name autocrine motility factor (AMF). Its cell surface receptor, gp78/AMFR, is also localized to the endoplasmic reticulum where it functions as an E3 ubiquitin ligase. Expression of both AMF/PGI and gp78/AMFR is associated with cancer and, in this review, we will discuss various aspects of the biology of this ligand–receptor complex and its role in tumor progression.

Graphical abstract: The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase

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Article information

DOI
https://doi.org/10.1039/B820820B
Article type
Review Article
Submitted
20 Nov 2008
Accepted
15 Apr 2009
First published
29 May 2009

Mol. BioSyst., 2009,5, 793-801

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The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase

M. Fairbank, P. St-Pierre and I. R. Nabi, Mol. BioSyst., 2009, 5, 793 DOI: 10.1039/B820820B

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