Polarographic determination of nitroxazepine hydrochloride in tablets

Abstract

A polarographic method has been developed for the quantitative determination of nitroxazepine hydrochloride in the pure form and in tablets by the aid of different buffer systems. The substance is extracted from the sample with water, the appropriate buffer of selected pH is added to an aliquot and the solution then polarographed at a dropping mercury electrode versus a standard calomel electrode. The resultant single reduction wave is well developed and permits a precise quantitative determination. The method of standard additions is used.