Issue 6, 2010
From the journal:

Green Chemistry

Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids†

Li-Chun Feng,a   Ya-Wei Sun,a   Wei-Jun Tang,a   Li-Jin Xu,*a   Kim-Lung Lam,b   Zhongyuan Zhoub  and  Albert S. C. Chanb  

* Corresponding authors

a Department of Chemistry, Renmin University of China, Beijing, China
E-mail: xulj@chem.ruc.edu.cn

b Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China

Abstract

The room temperature ionic liquid [bmim][PF6] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a L-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.

Graphical abstract: Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B926498A
Article type
Communication
Submitted
17 Dec 2009
Accepted
24 Mar 2010
First published
13 Apr 2010

Green Chem., 2010,12, 949-952

Permissions

Request permissions

Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids

L. Feng, Y. Sun, W. Tang, L. Xu, K. Lam, Z. Zhou and A. S. C. Chan, Green Chem., 2010, 12, 949 DOI: 10.1039/B926498A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements