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Issue 17, 2010
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Highly efficient Rh(I) and Ir(I) single and dual metal catalysed dihydroalkoxylation reactions of alkyne diols

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Abstract

A highly efficient rhodium(I) and iridium(I) catalysed dihydroalkoxylation reaction of alkyne diols is employed here for the synthesis of spiroketals and a fused bicyclic ketal. The two metal catalysts show differential selectivity and efficiency for either the cyclisation of the 5-exo or 6-endo-membered rings. For the first time, a dual metal (Rh and Ir) catalyst system is effectively utilised for the formation of the 5,6-spiroketals, more efficiently than the single metal catalysts. The two different metals create a dual activation pathway to enhance the 5- and 6-membered ring closure as compared with the equivalent single catalysts.

Graphical abstract: Highly efficient Rh(i) and Ir(i) single and dual metal catalysed dihydroalkoxylation reactions of alkyne diols

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Publication details

The article was received on 21 Dec 2009, accepted on 04 Feb 2010 and first published on 09 Mar 2010


Article type: Paper
DOI: 10.1039/B926773E
Dalton Trans., 2010,39, 4062-4069

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    Highly efficient Rh(I) and Ir(I) single and dual metal catalysed dihydroalkoxylation reactions of alkyne diols

    J. H. H. Ho, R. Hodgson, J. Wagler and B. A. Messerle, Dalton Trans., 2010, 39, 4062
    DOI: 10.1039/B926773E

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