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Issue 12, 2010
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Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

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Abstract

In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin® (octreotide) was allowed to react with Fe3(CO)12. An octreotide-Fe2(CO)6 complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H+ to H2. It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst1-5 receptors of octreotide.

Graphical abstract: Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

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Publication details

The article was received on 12 Oct 2009, accepted on 13 Jan 2010 and first published on 02 Feb 2010


Article type: Paper
DOI: 10.1039/B921299J
Dalton Trans., 2010,39, 3065-3071

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    Reaction of Fe3(CO)12 with octreotide—chemical, electrochemical and biological investigations

    U. Apfel, M. Rudolph, C. Apfel, C. Robl, D. Langenegger, D. Hoyer, B. Jaun, M. Ebert, T. Alpermann, D. Seebach and W. Weigand, Dalton Trans., 2010, 39, 3065
    DOI: 10.1039/B921299J

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