Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 4, 2010
Previous Article Next Article

Click chemistry under non-classical reaction conditions

Author affiliations


First described almost a decade ago, “click” reactions such as the Cu(I)-catalyzed azidealkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in the polymer and material science field, and in chemical biology. While most click reactions can be performed at room temperature there are instances where some form of process intensification is required. In this tutorial review, aimed at the synthetic chemistry community, examples of click chemistry carried out under non-classical reaction conditions, such as for example applying microwave heating or continuous flow processing will be highlighted.

Graphical abstract: Click chemistry under non-classical reaction conditions

Back to tab navigation

Article information

22 Apr 2009
First published
27 Jul 2009

Chem. Soc. Rev., 2010,39, 1280-1290
Article type
Tutorial Review

Click chemistry under non-classical reaction conditions

C. O. Kappe and E. Van der Eycken, Chem. Soc. Rev., 2010, 39, 1280
DOI: 10.1039/B901973C

Social activity

Search articles by author