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Issue 4, 2010
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Click chemistry under non-classical reaction conditions

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Abstract

First described almost a decade ago, “click” reactions such as the Cu(I)-catalyzed azidealkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in the polymer and material science field, and in chemical biology. While most click reactions can be performed at room temperature there are instances where some form of process intensification is required. In this tutorial review, aimed at the synthetic chemistry community, examples of click chemistry carried out under non-classical reaction conditions, such as for example applying microwave heating or continuous flow processing will be highlighted.

Graphical abstract: Click chemistry under non-classical reaction conditions

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Article information


Submitted
22 Apr 2009
First published
27 Jul 2009

Chem. Soc. Rev., 2010,39, 1280-1290
Article type
Tutorial Review

Click chemistry under non-classical reaction conditions

C. O. Kappe and E. Van der Eycken, Chem. Soc. Rev., 2010, 39, 1280
DOI: 10.1039/B901973C

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