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Issue 4, 2010
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Click chemistry under non-classical reaction conditions

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First described almost a decade ago, “click” reactions such as the Cu(I)-catalyzed azidealkyne cycloaddition (CuAAC) are widely used today in organic and medicinal chemistry, in the polymer and material science field, and in chemical biology. While most click reactions can be performed at room temperature there are instances where some form of process intensification is required. In this tutorial review, aimed at the synthetic chemistry community, examples of click chemistry carried out under non-classical reaction conditions, such as for example applying microwave heating or continuous flow processing will be highlighted.

Graphical abstract: Click chemistry under non-classical reaction conditions

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The article was received on 22 Apr 2009 and first published on 27 Jul 2009

Article type: Tutorial Review
DOI: 10.1039/B901973C
Citation: Chem. Soc. Rev., 2010,39, 1280-1290

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    Click chemistry under non-classical reaction conditions

    C. O. Kappe and E. Van der Eycken, Chem. Soc. Rev., 2010, 39, 1280
    DOI: 10.1039/B901973C

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