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Issue 11, 2010
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Molecular balances for quantifying non-covalent interactions

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Abstract

Molecular interactions underlie the whole of chemistry and biology. This tutorial review illustrates the use of rotameric folding molecules, topoisomers, atropoisomers, and tautomers as molecular balances for quantifying non-covalent interactions. This intramolecular approach enables a wide variety of interactions to be examined with a degree of geometric control that is difficult to achieve in supramolecular complexes. Synthetic variation of molecular balances allows the fundamental physicochemical origins of molecular recognition to be systematically examined by providing insights into the interplay of geometry and solvation on non-covalent interactions.

Graphical abstract: Molecular balances for quantifying non-covalent interactions

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Publication details

The article was received on 12 Apr 2010 and first published on 16 Sep 2010


Article type: Tutorial Review
DOI: 10.1039/B822665M
Citation: Chem. Soc. Rev., 2010,39, 4195-4205
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    Molecular balances for quantifying non-covalent interactions

    I. K. Mati and S. L. Cockroft, Chem. Soc. Rev., 2010, 39, 4195
    DOI: 10.1039/B822665M

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