Issue 1, 2010
From the journal:

Chemical Society Reviews

Biocatalytic carboxylation†

Silvia M. Glueck,ab   Selcuc Gümüs,‡b   Walter M. F. Fabianb  and  Kurt Faber*b  

* Corresponding authors

a Research Centre Applied Biocatalysis, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
E-mail: Kurt.Faber@Uni-graz.at
Fax: +43-316-380-9840
Tel: +43-316-380-5332

b Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria

Abstract

Dwindling petroleum feedstocks and increased CO2-concentrations in the atmosphere currently open the concept of using CO2 as raw material for the synthesis of well-defined organic compounds. In parallel to recent advances in the chemical CO2-fixation, enzymatic (biocatalytic) carboxylation is currently being investigated at an increased pace. On the one hand, this critical review provides a concise overview on highly specific biosynthetic pathways for CO2-fixation and, on the other hand, a summary of biodegradation (detoxification) processes involving enzymes which possess relaxed substrate specificities, which allow their application for the regioselective carboxylation of organic substrates to furnish the corresponding carboxylic acids (145 references).

Graphical abstract: Biocatalytic carboxylation

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Article information

DOI
https://doi.org/10.1039/B807875K
Article type
Critical Review
Submitted
06 Mar 2009
First published
08 Sep 2009

Chem. Soc. Rev., 2010,39, 313-328

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Biocatalytic carboxylation

S. M. Glueck, S. Gümüs, W. M. F. Fabian and K. Faber, Chem. Soc. Rev., 2010, 39, 313 DOI: 10.1039/B807875K

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