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Issue 44, 2010
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Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

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Abstract

We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a–b) and their Gd-complexes [Gd(L)(H2O)] (2a–b, L = 1a–b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

Graphical abstract: Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

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Article information


Submitted
10 Aug 2010
Accepted
13 Sep 2010
First published
01 Oct 2010

Chem. Commun., 2010,46, 8442-8444
Article type
Communication

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

H. Kim, J. Park, K. M. Kim, N. Sk Md., D. Kang, J. Lee, Y. Chang and T. Kim, Chem. Commun., 2010, 46, 8442
DOI: 10.1039/C0CC03145C

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