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Issue 43, 2010
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Total chemical synthesis of human proinsulin

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A convergent synthetic strategy based on modern chemical ligation methods was used to make human proinsulin. The synthetic protein was characterized by LCMS, CD spectroscopy, and by 1D- and 2D-NMR spectroscopy. Synthetic human proinsulin had full biochemical activity in a receptor-binding assay.

Graphical abstract: Total chemical synthesis of human proinsulin

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The article was received on 10 Aug 2010, accepted on 07 Sep 2010 and first published on 28 Sep 2010

Article type: Communication
DOI: 10.1039/C0CC03141K
Chem. Commun., 2010,46, 8177-8179

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    Total chemical synthesis of human proinsulin

    S. Luisier, M. Avital-Shmilovici, M. A. Weiss and S. B. H. Kent, Chem. Commun., 2010, 46, 8177
    DOI: 10.1039/C0CC03141K

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