Issue 42, 2010
From the journal:

Chemical Communications

Azirine ligation: fast and selective proteinconjugationvia photoinduced azirine–alkenecycloaddition†

Reyna K. V. Lima  and  Qing Lin*a  

* Corresponding authors

a Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA
E-mail: qinglin@buffalo.edu
Fax: +1 (716) 6456963
Tel: +1 (716) 645 4254

Abstract

We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine–alkene cycloaddition provides a rapid (∼2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.

Graphical abstract: Azirine ligation: fast and selective protein conjugation via photoinduced azirine–alkene cycloaddition

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Article information

DOI
https://doi.org/10.1039/C0CC02863K
Article type
Communication
Submitted
28 Jul 2010
Accepted
23 Aug 2010
First published
24 Sep 2010

Chem. Commun., 2010,46, 7993-7995

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Azirine ligation: fast and selective protein conjugation via photoinduced azirine–alkene cycloaddition

R. K. V. Lim and Q. Lin, Chem. Commun., 2010, 46, 7993 DOI: 10.1039/C0CC02863K

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