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Issue 41, 2010
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Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

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Abstract

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Graphical abstract: Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

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Publication details

The article was received on 28 Jul 2010, accepted on 23 Aug 2010 and first published on 20 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02852E
Chem. Commun., 2010,46, 7742-7744

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    Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

    K. Gorska, J. Beyrath, S. Fournel, G. Guichard and N. Winssinger, Chem. Commun., 2010, 46, 7742
    DOI: 10.1039/C0CC02852E

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