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Issue 43, 2010
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Phage display selection of miniprotein binders of the Estrogen Receptor

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Abstract

Miniprotein phage display screening yields structured peptides with high affinity for the Estrogen Receptor (ER). Hits from apamin phage libraries feature a LXXLL motif specifically placed on the predefined miniprotein helical segment. The apamin scaffold also allows optimization of flanking amino acids to ensure an optimal ER binding affinity.

Graphical abstract: Phage display selection of miniprotein binders of the Estrogen Receptor

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Publication details

The article was received on 22 Jul 2010, accepted on 10 Sep 2010 and first published on 27 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02727H
Chem. Commun., 2010,46, 8207-8209

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    Phage display selection of miniprotein binders of the Estrogen Receptor

    T. Phan, H. D. Nguyen, H. Göksel, S. Möcklinghoff and L. Brunsveld, Chem. Commun., 2010, 46, 8207
    DOI: 10.1039/C0CC02727H

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