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Issue 41, 2010
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Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

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Abstract

A novel preparation of sodium [18F]-fluoroacetate is described where 5′-[18F]-fluoro-5′-deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [18F]-fluoride and then oxidation to [18F]-fluoroacetate by a Kuhn–Roth oxidative degradation.

Graphical abstract: Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

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Publication details

The article was received on 30 Jun 2010, accepted on 17 Aug 2010 and first published on 20 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02264K
Chem. Commun., 2010,46, 7819-7821

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    Fluorinase mediated chemoenzymatic synthesis of [18F]-fluoroacetate

    X. Li, J. Domarkas and D. O'Hagan, Chem. Commun., 2010, 46, 7819
    DOI: 10.1039/C0CC02264K

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