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Issue 34, 2010
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Synthesis of MUC1–lipopeptide chimeras

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Abstract

An efficient method for the convergent assembly of MUC1–lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.

Graphical abstract: Synthesis of MUC1–lipopeptide chimeras

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Supplementary files

Article information


Submitted
12 May 2010
Accepted
25 Jun 2010
First published
28 Jul 2010

Chem. Commun., 2010,46, 6249-6251
Article type
Communication

Synthesis of MUC1–lipopeptide chimeras

B. L. Wilkinson, L. R. Malins, C. K. Y. Chun and R. J. Payne, Chem. Commun., 2010, 46, 6249
DOI: 10.1039/C0CC01360A

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