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Issue 44, 2010
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Click-based synthesis and proteomic profiling of lipstatin analogues

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Abstract

Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.

Graphical abstract: Click-based synthesis and proteomic profiling of lipstatin analogues

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Publication details

The article was received on 07 May 2010, accepted on 10 Jun 2010 and first published on 24 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC01276A
Chem. Commun., 2010,46, 8335-8337

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    Click-based synthesis and proteomic profiling of lipstatin analogues

    M. H. Ngai, P. Yang, K. Liu, Y. Shen, M. R. Wenk, S. Q. Yao and M. J. Lear, Chem. Commun., 2010, 46, 8335
    DOI: 10.1039/C0CC01276A

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