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Issue 37, 2010
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Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

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Abstract

pqqD is one of six genes required for PQQ production in Klebsiella pneumoniae. Herein, we demonstrate that PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe–4S]+ clusters. This interaction redirects the role for PqqD in PQQ biosynthesis.

Graphical abstract: Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

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Publication details

The article was received on 15 Apr 2010, accepted on 16 Jul 2010 and first published on 25 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC00968G
Chem. Commun., 2010,46, 7031-7033

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    Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

    S. R. Wecksler, S. Stoll, A. T. Iavarone, E. M. Imsand, H. Tran, R. D. Britt and J. P. Klinman, Chem. Commun., 2010, 46, 7031
    DOI: 10.1039/C0CC00968G

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