Issue 31, 2010
From the journal:

Chemical Communications

Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes†

Hidenobu Yaku,ab   Takashi Murashima,bc   Daisuke Miyoshi*bc  and  Naoki Sugimoto*bc  

* Corresponding authors

a Advanced Technology Research Laboratories, Panasonic Corporation, 3-4 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan

b FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
E-mail: miyoshi@center.konan-u.ac.jp, sugimoto@konan-u.ac.jp

c FIRST (Faculty of Frontiers of Innovative Research in Science and Technology), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

Abstract

Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction under conditions with dsDNA.

Graphical abstract: Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes

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Article information

DOI
https://doi.org/10.1039/C0CC00956C
Article type
Communication
Submitted
15 Apr 2010
Accepted
16 Jun 2010
First published
01 Jul 2010

Chem. Commun., 2010,46, 5740-5742

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Anionic phthalocyanines targeting G-quadruplexes and inhibiting telomerase activity in the presence of excessive DNA duplexes

H. Yaku, T. Murashima, D. Miyoshi and N. Sugimoto, Chem. Commun., 2010, 46, 5740 DOI: 10.1039/C0CC00956C

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