Issue 28, 2010

Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles

Abstract

Three-component reactions with 3,4-diiodoalk-2-enoic derivatives, primary amines, and terminal alkynes proceeded to give trisubstituted pyrroles in fair to good yields in the presence of palladium and copper catalysts under mild reaction conditions.

Graphical abstract: Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2010
Accepted
13 May 2010
First published
07 Jun 2010

Chem. Commun., 2010,46, 5157-5159

Domino allylic amination/Sonogashira/heterocyclisation reactions: palladium-catalysed three-component synthesis of pyrroles

S. Lamandé-Langle, M. Abarbri, J. Thibonnet, A. Duchêne and J. Parrain, Chem. Commun., 2010, 46, 5157 DOI: 10.1039/C0CC00500B

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