Issue 30, 2010
From the journal:

Chemical Communications

Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites†

Yun Xie,a   Andrew V. Dixa  and  Yitzhak Tor*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA
E-mail: ytor@ucsd.edu

Abstract

A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic.

Graphical abstract: Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites

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Article information

DOI
https://doi.org/10.1039/C0CC00423E
Article type
Communication
Submitted
16 Mar 2010
Accepted
21 Apr 2010
First published
13 May 2010

Chem. Commun., 2010,46, 5542-5544

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Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites

Y. Xie, A. V. Dix and Y. Tor, Chem. Commun., 2010, 46, 5542 DOI: 10.1039/C0CC00423E

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