Issue 31, 2010
From the journal:

Chemical Communications

Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes†

Nishima Wangoo,ab   Jyotsna Kaushal,c   K. K. Bhasin,b   S. K. Mehtab  and  C. Raman Suri*a  

* Corresponding authors

a Institute of Microbial Technology (CSIR), Sector 39-A, Chandigarh 160014, India
E-mail: raman@imtech.res.in

b Chitkara Institute of Engineering & Technology, Rajpura, Distt. Patiala, India

c Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India

Abstract

A one-step homogeneous colorimetric immunoassay format coupled with zeta potential measurements for determination of specific diabetic biomarker glycated hemoglobin (HbA1c) using functionalised gold nanoparticles as bioprobes is reported. The assay exhibited an excellent sensitivity based on absorbance and zeta potential measurements showing the dynamic response range from 0.001–0.004 mg mL−1 for HbA1c with a detection limit of 0.0015 mg mL−1.

Graphical abstract: Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes

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Article information

DOI
https://doi.org/10.1039/C0CC00224K
Article type
Communication
Submitted
04 Mar 2010
Accepted
27 May 2010
First published
23 Jun 2010

Chem. Commun., 2010,46, 5755-5757

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Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes

N. Wangoo, J. Kaushal, K. K. Bhasin, S. K. Mehta and C. R. Suri, Chem. Commun., 2010, 46, 5755 DOI: 10.1039/C0CC00224K

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