Issue 31, 2010

Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes

Abstract

A one-step homogeneous colorimetric immunoassay format coupled with zeta potential measurements for determination of specific diabetic biomarker glycated hemoglobin (HbA1c) using functionalised gold nanoparticles as bioprobes is reported. The assay exhibited an excellent sensitivity based on absorbance and zeta potential measurements showing the dynamic response range from 0.001–0.004 mg mL−1 for HbA1c with a detection limit of 0.0015 mg mL−1.

Graphical abstract: Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2010
Accepted
27 May 2010
First published
23 Jun 2010

Chem. Commun., 2010,46, 5755-5757

Zeta potential based colorimetric immunoassay for the direct detection of diabetic marker HbA1c using gold nanoprobes

N. Wangoo, J. Kaushal, K. K. Bhasin, S. K. Mehta and C. R. Suri, Chem. Commun., 2010, 46, 5755 DOI: 10.1039/C0CC00224K

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