Issue 24, 2010
From the journal:

Chemical Communications

Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI†

Daniel T. Schühle,a   Patrick van Rijn,b   Sophie Laurent,c   Luce Vander Elst,c   Robert N. Muller,c   Marc C. A. Stuart,d   Jürgen Schatze  and  Joop A. Peters*a  

* Corresponding authors

a Delft University of Technology, Department of Biotechnology, Biocatalysis and Organic Chemistry, Julianalaan 136, 2628 BL Delft, The Netherlands
E-mail: j.a.peters@tudelft.nl
Tel: +31152785892

b Delft University of Technology, Department of Chemical Engineering, Self Assembling Systems, Julianalaan 136, The Netherlands

c Department of General, Organic and Biomedical Chemistry, University of Mons, Place du Parc, 20 B-7000 Mons, Belgium

d University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, Electron Microscopy Group, Nijenborgh 4, 9747 AG Groningen, The Netherlands

e University of Erlangen-Nürnberg, Department of Chemistry and Pharmacy, Henkestraße 42, 91054 Erlangen, Germany

Abstract

Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

Graphical abstract: Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

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Article information

DOI
https://doi.org/10.1039/C0CC00107D
Article type
Communication
Submitted
24 Feb 2010
Accepted
20 Apr 2010
First published
13 May 2010

Chem. Commun., 2010,46, 4399-4401

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Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

D. T. Schühle, P. van Rijn, S. Laurent, L. Vander Elst, R. N. Muller, M. C. A. Stuart, J. Schatz and J. A. Peters, Chem. Commun., 2010, 46, 4399 DOI: 10.1039/C0CC00107D

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