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Issue 30, 2010
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Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situcofactorregeneration

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Abstract

Enantiopure chiral amines synthesis using ω-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.

Graphical abstract: Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

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Publication details

The article was received on 21 Feb 2010, accepted on 28 Apr 2010 and first published on 12 May 2010


Article type: Communication
DOI: 10.1039/C0CC00050G
Chem. Commun., 2010,46, 5569-5571

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    Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

    K. E. Cassimjee, C. Branneby, V. Abedi, A. Wells and P. Berglund, Chem. Commun., 2010, 46, 5569
    DOI: 10.1039/C0CC00050G

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