Issue 30, 2010

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situcofactorregeneration

Abstract

Enantiopure chiral amines synthesis using ω-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.

Graphical abstract: Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2010
Accepted
28 Apr 2010
First published
12 May 2010

Chem. Commun., 2010,46, 5569-5571

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

K. E. Cassimjee, C. Branneby, V. Abedi, A. Wells and P. Berglund, Chem. Commun., 2010, 46, 5569 DOI: 10.1039/C0CC00050G

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