Issue 20, 2010
From the journal:

Chemical Communications

Novel heteronuclear ruthenium–copper coordination compounds as efficient DNA-cleaving agents†

Stefanie van der Steen,a   Paul de Hoog,a   Karlijn van der Schilden,a   Patrick Gamez,a   Marguerite Pitié,b   Robert Kissc  and  Jan Reedijk*a  

* Corresponding authors

a Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
E-mail: reedijk@chem.leidenuniv.nl
Fax: (+31) 71-527-4671

b Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, 31077 Toulouse cedex, 4, France

c Laboratoire de Toxicologie, Institut de Pharmacie, Université Libre de Bruxelles (ULB), Boulevard du Triomphe, 1050 Bruxelles, Belgium

Abstract

The DNA-cleavage ability of novel bifunctional heterobimetallic copper–ruthenium complexes is demonstrated by using gel electrophoresis.

Graphical abstract: Novel heteronuclear ruthenium–copper coordination compounds as efficient DNA-cleaving agents

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Article information

DOI
https://doi.org/10.1039/C000077A
Article type
Communication
Submitted
06 Jan 2010
Accepted
22 Feb 2010
First published
22 Mar 2010

Chem. Commun., 2010,46, 3568-3570

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Novel heteronuclear ruthenium–copper coordination compounds as efficient DNA-cleaving agents

S. van der Steen, P. de Hoog, K. van der Schilden, P. Gamez, M. Pitié, R. Kiss and J. Reedijk, Chem. Commun., 2010, 46, 3568 DOI: 10.1039/C000077A

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