Issue 18, 2010
From the journal:

Chemical Communications

Thymine, adenine and lipoamino acid based gene delivery systems†

Mariusz Skwarczynski,a   Zyta M. Ziora,b   Daniel J. Coles,a   I-Chun Lina  and  Istvan Toth*ab  

* Corresponding authors

a The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, Australia
E-mail: i.toth@uq.edu.au
Fax: +61 7 3365 1688
Tel: +61 7 3346 9892

b The University of Queensland, Centre for Integrated Preclinical Drug Development (CIPDD), TetraQ-Pharmaceutics, Brisbane, Australia

Abstract

A novel class of thymine, adenine and lipoamino acid based non-viral carriers for gene delivery has been developed. Their ability to bind to DNA by hydrogen bonding was confirmed by NMR diffusion, isothermal titration calorimetry and transmission electron microscopy experiments.

Graphical abstract: Thymine, adenine and lipoamino acid based gene delivery systems

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Article information

DOI
https://doi.org/10.1039/B924371B
Article type
Communication
Submitted
20 Nov 2009
Accepted
10 Feb 2010
First published
05 Mar 2010

Chem. Commun., 2010,46, 3140-3142

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Thymine, adenine and lipoamino acid based gene delivery systems

M. Skwarczynski, Z. M. Ziora, D. J. Coles, I. Lin and I. Toth, Chem. Commun., 2010, 46, 3140 DOI: 10.1039/B924371B

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