Issue 13, 2010
From the journal:

Chemical Communications

Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group†

Satoshi Yamaguchi,a   Yanjie Chen,a   Soh Nakajima,a   Toshiaki Furutad  and  Teruyuki Nagamune*abc  

* Corresponding authors

a Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: nagamune@bioeng.t.u-tokyo.ac.jp
Fax: +81 (0)3 5841 8657
Tel: +81 (0)3 5841 7328

b Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan

c Center for NanoBio Integration (CNBI), The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan

d Department of Biomolecular Science, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

A new method for site-specific caging of plasmidDNA was developed to enable light-activation of gene expression in living cells by exposure to a low dose of light.

Graphical abstract: Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group

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Article information

DOI
https://doi.org/10.1039/B922502A
Article type
Communication
Submitted
27 Oct 2009
Accepted
21 Dec 2009
First published
20 Jan 2010

Chem. Commun., 2010,46, 2244-2246

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Light-activated gene expression from site-specific caged DNA with a biotinylated photolabile protection group

S. Yamaguchi, Y. Chen, S. Nakajima, T. Furuta and T. Nagamune, Chem. Commun., 2010, 46, 2244 DOI: 10.1039/B922502A

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