Issue 2, 2010
From the journal:

Chemical Communications

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin†

Ian Paterson,*a   Guy J. Naylor,a   Takeshi Fujita,a   Esther Guzmánb  and  Amy E. Wrightb  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK,
E-mail: ip100@cam.ac.uk
Fax: +44 (0)1223 336362
Tel: +44 (0)1223 336407

b Harbor Branch Oceanographic Institution at Florida Atlantic University, 5600 US 1 North, Ft. Pierce, USA

Abstract

A hybrid library of the marine natural productsdictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.

Graphical abstract: Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

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Article information

DOI
https://doi.org/10.1039/B921237J
Article type
Communication
Submitted
13 Oct 2009
Accepted
10 Nov 2009
First published
24 Nov 2009

Chem. Commun., 2010,46, 261-263

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Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

I. Paterson, G. J. Naylor, T. Fujita, E. Guzmán and A. E. Wright, Chem. Commun., 2010, 46, 261 DOI: 10.1039/B921237J

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