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Issue 5, 2010
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Direct selective oxygen-assisted acylation of amines driven by metallic silver surfaces: dimethylamine with formaldehyde

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Abstract

Facile, direct acylation of dimethylamine with formaldehyde to N,N-dimethylformamide proceeds with a selectivity approaching 100% at low oxygen concentrations on metallic silver surfaces; the reaction proceeds via nucleophilic attack of adsorbed dimethylamide on formaldehyde with subsequent β-H elimination from the adsorbed hemiaminal.

Graphical abstract: Direct selective oxygen-assisted acylation of amines driven by metallic silver surfaces: dimethylamine with formaldehyde

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Article information


Submitted
08 Oct 2009
Accepted
07 Dec 2009
First published
21 Dec 2009

Chem. Commun., 2010,46, 704-706
Article type
Communication

Direct selective oxygen-assisted acylation of amines driven by metallic silver surfaces: dimethylamine with formaldehyde

L. Zhou, C. G. Freyschlag, B. Xu, C. M. Friend and R. J. Madix, Chem. Commun., 2010, 46, 704
DOI: 10.1039/B921066K

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