Jump to main content
Jump to site search

Issue 13, 2010
Previous Article Next Article

Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)

Author affiliations

Abstract

(+)-Scyphostatin (1) was synthesized via (i) construction of a side-chain 3b of ≥98% purity in 19% yield in eleven steps featuring ZACA reaction, Negishi coupling, and HWE olefination, (ii) an asymmetric synthesis of a fully protected core 4 from 10a, and (iii) a three-step assembly of 1 in 42% yield.

Graphical abstract: Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Sep 2009, accepted on 09 Feb 2010 and first published on 23 Feb 2010


Article type: Communication
DOI: 10.1039/B920261G
Citation: Chem. Commun., 2010,46, 2200-2202
  •   Request permissions

    Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)

    E. Pitsinos, N. Athinaios, Z. Xu, G. Wang and E. Negishi, Chem. Commun., 2010, 46, 2200
    DOI: 10.1039/B920261G

Search articles by author

Spotlight

Advertisements