Issue 6, 2010
From the journal:

Chemical Communications

A quartz crystal microbalance-based molecular ruler for biopolymers†

Hongwei Ma,*ab   Jian’an He,b   Zhiqiang Zhu,c   Bei’er Lv,a   Di Li,c   Chunhai Fanc  and  Jing Fangb  

* Corresponding authors

a Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215125, P.R. China
E-mail: hwma2008@sinano.ac.cn
Fax: 0086 512 62872562
Tel: 0086 512 62872539

b Biomed-X Research Center, Academy of Advanced Interdisciplinary Studies, Peking University, Beijing 100871, P.R. China

c Shanghai Institute of Applied Physics Chinese Academy of Sciences, Shanghai 201800, P.R. China

Abstract

We developed a quartz crystal microbalance (QCM) based molecular ruler that measures the length of surface immobilized, hydrated biopolymers (DNA and proteins). These biopolymers acted as stakes that solidified surrounding liquid at high frequency vibration in QCM measurements, which led to a simple linear frequency–thickness relation.

Graphical abstract: A quartz crystal microbalance-based molecular ruler for biopolymers

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Article information

DOI
https://doi.org/10.1039/B919179H
Article type
Communication
Submitted
16 Sep 2009
Accepted
18 Nov 2009
First published
09 Dec 2009

Chem. Commun., 2010,46, 949-951

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A quartz crystal microbalance-based molecular ruler for biopolymers

H. Ma, J. He, Z. Zhu, B. Lv, D. Li, C. Fan and J. Fang, Chem. Commun., 2010, 46, 949 DOI: 10.1039/B919179H

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