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Issue 9, 2010
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Magnetic relaxation-based platform for multiplexed assays

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Abstract

We explore the use of magnetic relaxation sensors as an in vitro assay platform. Functionalized magnetic nanoparticles that exhibit transverse relaxation time (T2) changes with the introduction of an analyte have previously been used to detect proteins, antibodies, receptor ligands, peptides, nucleic acids, oligonucleotides, and other small molecules. The standard procedure for sensitizing particles towards specific targets is, however, time-consuming and cumbersome. We report here a new approach that exploits primary–secondary antibody binding for easily derivatizing particles against specific targets. The assay is shown to be quantitative and a multiplexed assay against three target analytes is demonstrated.

Graphical abstract: Magnetic relaxation-based platform for multiplexed assays

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Article information


Submitted
09 Dec 2009
Accepted
02 Jun 2010
First published
13 Jul 2010

Analyst, 2010,135, 2360-2364
Article type
Paper

Magnetic relaxation-based platform for multiplexed assays

Y. Ling, C. C. Vassiliou and M. J. Cima, Analyst, 2010, 135, 2360
DOI: 10.1039/B926041M

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