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Issue 5, 2010
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Neutron reflectometry of supported hybrid bilayers with inserted peptide

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Abstract

The insertion of a synthetic amphiphilic, α-helical peptide into a supported hybrid bilayer membrane (HBM) was studied by neutron reflectometry to elucidate the resulting nanostructure. The HBM consisted of a self-assembled monolayer of perdeuterated octadecanethiol on gold and an overlying leaflet of acyl-deuterated phosphatidylcholine (d-DMPC). Using contrast variation, several reflectivity spectra were recorded for each step of film fabrication, and simultaneously modeled. This analysis indicated that peptide insertion into the DMPC lipid leaflet is the likeliest mode of incorporation.

Graphical abstract: Neutron reflectometry of supported hybrid bilayers with inserted peptide

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Article information


Submitted
03 Aug 2009
Accepted
07 Dec 2009
First published
04 Jan 2010

Soft Matter, 2010,6, 862-865
Article type
Communication

Neutron reflectometry of supported hybrid bilayers with inserted peptide

M. B. Smith, D. J. McGillivray, J. Genzer, M. Lösche and P. K. Kilpatrick, Soft Matter, 2010, 6, 862
DOI: 10.1039/B915800F

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