Issue 19, 2010
From the journal:

Soft Matter

A nano-fibrous assembly of collagen–hyaluronic acid for controlling cell-adhesive properties†

Toshinori Fujie,a   Sho Furutate,a   Daisuke Niwaa  and  Shinji Takeoka*ab  

* Corresponding authors

a Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, Tokyo, Japan
E-mail: takeoka@waseda.jp
Fax: +813-5369-7324
Tel: +813-5369-7324

b High-Tech Research Center, Waseda University, Tokyo, Japan

Abstract

We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechano-biological approach for the development of tissue-engineering scaffolds.

Graphical abstract: A nano-fibrous assembly of collagen–hyaluronic acid for controlling cell-adhesive properties

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Article information

DOI
https://doi.org/10.1039/C0SM00527D
Article type
Communication
Submitted
14 Jun 2010
Accepted
15 Jul 2010
First published
20 Aug 2010

Soft Matter, 2010,6, 4672-4676

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A nano-fibrous assembly of collagen–hyaluronic acid for controlling cell-adhesive properties

T. Fujie, S. Furutate, D. Niwa and S. Takeoka, Soft Matter, 2010, 6, 4672 DOI: 10.1039/C0SM00527D

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