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Issue 2, 2010
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Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients

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Abstract

Local signaling, cell polarization, and protrusive growth are key steps in directed migration of biological cells guided by chemical gradients. Here we present a minimal system which captures several key features of cellular migration from signaling-to-motion. The model system consists of flat, negatively charged phospholipid vesicles, a negatively charged surface, and a local, and controllable point-source supply of calcium ions. In the presence of a Ca2+ gradient, the surface-adhered vesicles form protrusions in the direction of the gradient. We also observe membrane shape oscillations between expanded (flattened), and spherical states as a function of the Ca2+-concentration. The observed phenomena can be of importance in explaining motile action in prebiotic, primitive, and biomimetic systems, as well as in development of novel soft-matter nano- and microscale mechanical devices.

Graphical abstract: Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients

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Article information


Submitted
13 Aug 2009
Accepted
07 Oct 2009
First published
17 Nov 2009

Soft Matter, 2010,6, 268-272
Article type
Paper

Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients

T. Lobovkina, I. Gözen, Y. Erkan, J. Olofsson, S. G. Weber and O. Orwar, Soft Matter, 2010, 6, 268
DOI: 10.1039/B916805M

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