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Issue 9, 2010

Hydrolysable polylactide–polyphosphazene block copolymers for biomedical applications: synthesis, characterization, and composites with poly(lactic-co-glycolic acid)

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Abstract

This is the first reported synthesis of completely hydrolysable polyphosphazene block co-polymers with bioerodible polyesters. Specifically, poly[(lactic acid)-co-poly(bis-alanine ethyl ester phosphazene)], poly[(lactic acid)-co-poly(bis-valine ethyl ester phosphazene)], and poly[(lactic acid)-co-poly(bis-phenylalanine ethyl ester phosphazene)] block copolymers have been prepared. These block co-polymers are blend compatibilizers used to form miscible polymer systems between poly(lactic-co-glycolic acid) (PLAGA) (50 : 50) or PLAGA (85 : 15) and poly[(bis-alanine ethyl ester phosphazene)], poly[(bis-valine ethyl ester phosphazene)], or poly[(bis-phenylalanine ethyl ester phosphazene)]. The resultant combined systems were characterized using differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) to investigate polymer miscibility. The rates of hydrolysis and pH of the hydrolysis media were also examined.

Graphical abstract: Hydrolysable polylactide–polyphosphazene block copolymers for biomedical applications: synthesis, characterization, and composites with poly(lactic-co-glycolic acid)

Article information


Submitted
11 May 2010
Accepted
08 Jun 2010
First published
10 Aug 2010

Polym. Chem., 2010,1, 1459-1466
Article type
Paper

Hydrolysable polylactide–polyphosphazene block copolymers for biomedical applications: synthesis, characterization, and composites with poly(lactic-co-glycolic acid)

A. L. Weikel, S. Y. Cho, N. L. Morozowich, L. S. Nair, C. T. Laurencin and H. R. Allcock, Polym. Chem., 2010, 1, 1459 DOI: 10.1039/C0PY00150C

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